Relatively higher levels of plasma TDP-43 were found in the FTD (0.356 ± 0.202 pg/ml, p < 0.0001) than in the NC group (0.165 ± 0.062 pg/ml), AD family (0.154 ± 0.106 pg/ml) and PD family (0.116 ± 0.075 pg/ml). This evidence concerns the gene TARDBP and frontotemporal dementia.