We found that IL-10 transcript was significantly upregulated only in GG patients (log2 fold-change, FC = 1.019) (Fig. 1) whilst its receptors (IL-10Rα and IL-10Rβ) and STAT3 were upregulated in both GG (IL-10Rα log2FC = 1.775; IL-10Rβ log2FC = 0.956; STAT3 log2FC = 0.622) and TSC (IL-10Rα log2FC = 1.212; IL-10Rβ log2FC = 0.534; STAT3 log2FC = 0.527) (Fig. 1). This evidence concerns the gene IL10RB and tuberous sclerosis.