Unsupervised clustering identified an effector CD8+ T cell subset (CD8+CD45ROlow) and a memory CD4+ T cell subset (CD4+CD45RO+TCF7+CD28+BTLA+TIGIT+) that were increased in posttreatment tumour specimens versus pretreatment in patients with favourable response (Fig. 4b,c). This evidence concerns the gene CD4 and neoplasm.