This is the case of three Proteasome-Associated Autoinflammatory Syndromes (PRAAS1 (Mondo:0054698), PRAAS3 (Mondo:0054699), and PRAAS5 (Mondo:0030924)) caused by variations on three proteasome subunits (subunit beta type-8 (P28062), subunit beta type-9 (P28065), and subunit beta type-10 (P40306), respectively). The gene discussed is PSMB8; the disease is autoinflammatory syndrome.