It is worth noticing that three non-enzyme genes (and therefore not directly present in DAR, although downloadable directly from the Reactome link) are also associated with osteogenesis imperfecta type 2; all are part of the same pathway, two as substrates (Collagen alpha-1(I) chain, P02452 and Collagen alpha-2(I) chain, P08123) and one as auxiliary protein (Cartilage-associated protein, O75718). This evidence concerns the gene COL1A2 and osteogenesis imperfecta type 2.