RUNX2 and osteoporosis: Osteoporosis is a disorder characterized by the deterioration of the bone tissue, and mainly due to the impairment of bone homeostasis, where SRC plays a central role (it promotes bone resorption by osteoclasts and suppresses bone formation by osteoblasts9), as it is also described in the Reactome pathway R-HAS-8940973 (RUNX2 regulates osteoblast differentiation).