Intriguingly, a recent aged-matched case–control study on 51 non-hepatitis ∝-thalassemia major patients disclosed that the hepcidin/ferritin ratio could be a more appropriate tool to predict iron overload-induced liver fibrosis and discriminate its stages with acceptable sensitivity and specificity than the hepcidin and ferritin alone. The gene discussed is HAMP; the disease is thalassemia.