The IFN-γ-induced chemokines CXCL9 or CXCL10, and their common receptor CXCR3, are upregulated in the gut of IBD patients27, A recent study suggested that the myeloid-cell-specific adaptor protein, MyD88, signaling, as well as the cytokines IL-12, IL-23, and IFN-γ, are closely involved in the pathogenesis of colon inflammation in NEMOtamIEC-KO mice28. This evidence concerns the gene MYD88 and inflammatory bowel disease.