Consistent with our earlier analyses examining E17.5 forebrain tissues (Supplementary Fig. 3), odds-ratio assessments revealed significant overlaps with human DS associated gene expression, specifically for PCGs upregulated in Ts65Dn vs. euploid, and for those downregulated in Ts65Dn;Brwd1+/– vs. Ts65Dn animals, indicating that Brwd1 copy number restoration significantly reverses trisomic gene expression patterns in Ts65Dn male hippocampus that are relevant to human DS (Fig. 2c). Here, BRWD1 is linked to Dravet syndrome.