Strong K177 acetylation signals were observed in three out of five in situ breast cancer tissues, whereas tumor tissues with node metastasis showed undetectable or largely reduced acetyl-METTL3 signals (Fig. 7k), suggestive of an inverse correlation between METTL3 acetylation and breast cancer metastasis in the clinical samples. The gene discussed is METTL3; the disease is breast carcinoma.