Treatment of TAC-operated mice with PPZ2 significantly improved LV dysfunctions and structural remodeling, such as myocardial hypertrophy and interstitial fibrosis, in a TRPC6-dependent manner (Fig. 6b–d, Supplementary Fig. 8a and Supplementary Tables 3 and 4). The gene discussed is TRPC6; the disease is cardiac hypertrophy.