Our previous studies using TRPC3-deficient mice have revealed that TRPC3 contributes to oxidative stress-related heart failure through a protein–protein interaction with NADPH oxidase (Nox) 215–17, but TRPC6-deficient mice revealed that TRPC6 negatively regulates TRPC3-Nox2 interaction and oxidative stress15,18. This evidence concerns the gene TRPC3 and heart failure.