IFNB1 and neoplasm: We find that FLICs-loaded hydrogel implants confer external control of the location and timing of IFN-β, TNF-α, and IL-12 expression upon illumination with a non-invasive FRL LED light, and confirm that this activated both the innate and adaptive immune systems, thereby preventing tumor recurrence and substantially outperforming soluble immunotherapeutic cytokine administration.