More importantly, we found a significant increase in the SCNAs encompassing genes from the PI3K and RAS pathways, compared to other cancer genes, in the context of MYC amplification or gain in the TCGA cohorts (TCGA breast cohort p-value = 0.0001; TCGA lung cohort p-value<0.0001; Fig. 5a, c). Here, PIK3CA is linked to cancer.