Most strikingly, HGSOC spheroids with MYC-amplification were also more sensitive to dual m-TORC1/2 inhibition than tumour samples with normal MYC copy number (Fig. 3g, h, Welch p-value = 0.02; Jonckheere-Terpstra p-value = 0.08). This evidence concerns the gene CRTC1 and neoplasm.