CNOT12 and neoplasm: These findings suggest that silencing TAB182 in ESCC cells reduces the capacity of metastatic ESCC cells to migrate and invade, which is consistent with our findings in Table 1, which showed that TAB182 expression was strongly linked to tumor invasion depth (P = 0.002), lymph node metastasis (P = 0.0001), and TNM stage (P = 0.003).