BMP4 and Increased total leukocyte count: Moreover, when we treated the injured WT and NSE-BMP4 mice with the mTOR inhibitor rapamycin for 2 weeks, the rapamycin-treated NSE-BMP4 mice still had high ActA levels, even though these animals exhibited the same blockade in HO and attenuated leukocytosis that we observed earlier (Fig. S17b).