Moreover, when we treated the injured WT and NSE-BMP4 mice with the mTOR inhibitor rapamycin for 2 weeks, the rapamycin-treated NSE-BMP4 mice still had high ActA levels, even though these animals exhibited the same blockade in HO and attenuated leukocytosis that we observed earlier (Fig. S17b). This evidence concerns the gene ACTA1 and Increased total leukocyte count.