GPX4 and cancer: In addition to GPX4, ferroptosis suppressor protein 1 (FSP1) is another ferroptosis inhibitor by inducing ubiquinol (CoQ10H2) generation from ubiquinone (CoQ10), and then FSP1-CoQ10-NAP(p)H pathway reduces lipid peroxidation accumulation resulting in inhibition of cancer cell ferroptosis [48, 49].