As an important regulator of iron uptake, TFR1 undergoes ubiquitination and degradation by β-TRCP E3 ligase in a tribbles pseudokinase 2 (TRIB2)-dependent manner, consequently blocks ferroptosis in live cancer cells [64], but how does TRIB2 affect βTRCP-mediated TFR1 degradation? The gene discussed is TFRC; the disease is cancer.