Meanwhile, homozygous CNV analysis showed that TOP1MT in 31 cancer types, TOP2A in 20 cancer types, TOP1 in 19 cancer types, TOP3B in 21 cancer types, TOP3A in 14 cancer types, and TOP2B in 17 cancer types occurred homozygous amplifications, while TOP1MT in 14 cancer types, TOP2A in 14 cancer types, TOP1 in 9 cancer types, TOP3B in 20 cancer types, TOP3A in 18 cancer types, and TOP2B in 14 cancer types occurred homozygous deletions (S3B Fig). The gene discussed is TOP1; the disease is cancer.