The high expression of TOP2A in LGG, KIRC, KICH, KIRP, LIHC, SKCM, ACC, LUAD and MESP; TOP3B in KIRC; TOP1MT in HNSC, KIRC and LIHC; TOP3A in LGG, KICH and THCA; TOP1 in LGG, ESCA and SARC was associated with poor survival, while the high expression of TOP2A in READ; TOP3B in LGG, HNSC, BRCA, KIRP, THYM and OV; TOP1MT in SKCM; TOP3A in THYM; TOP2B in HNSC and READ was associated with good survival (Fig 1E). Here, TOP3B is linked to reading.