The loss of dopaminergic inhibition results in hyperplasia, microadenoma or macroadenoma formation of the pars intermedia, and overproduction of POMC derived peptides including ACTH, α-MSH, β-END and corticotropin like intermediate lobe peptide (CLIP) [4,9,10,11,12,13].The presence of clinical signs such as hypertrichosis, lethargy, muscle atrophy, pendulous abdomen, polydipsia/polyuria (PU/PD), hyperhidrosis, anhidrosis, and recurrent infections all raise suspicion of PPID [3,14,15,16,17]. The gene discussed is POMC; the disease is anhidrosis.