During the inflammatory process, mediators such as cytokines, prostaglandins, and matrix metalloproteinases (MMP) are released and pro-inflammatory transcription factors are activated, such as NF-κB and the transducer and transcription activator signal 3 (STAT3), which play an important role in suppressing apoptosis, proliferation, angiogenesis, invasion, and tumor metastasis. The gene discussed is STAT3; the disease is neoplasm.