We recently demonstrated that JRTs with GI neoplastic polyps harbor an identical heterozygous germline variant in the adenomatous polyposis coli (APC) gene, c.[462_463delinsTT] (GenBank ID: LC598892.1), indicating that this is an autosomal dominant hereditary disorder (OMIA ID 001916–9615) [2]. The gene discussed is APC; the disease is autosomal dominant disease.