As KRAS mutations occur at a high frequency in human ductal pancreatic carcinomas (although rarely in pancreatic acinar cell carcinomas), all studies on pancreatic carcinoma in felines to date have focused on the mutational status of KRAS (in particular codon 12, which is a hotspot in human cancers) [132]. This evidence concerns the gene KRAS and exocrine pancreatic carcinoma.