Through clinical, experimental and animal studies, neurohormones such as epinephrine and norepinephrine (NE) of the sympathetic system, and angiotensin II (Ang II) and aldosterone of the renin–angiotensin–aldosterone system (RAAS) have been identified as the most important neurohormones stimulating pathological cardiac hypertrophy [21,22,23], particularly the RAAS. This evidence concerns the gene AGT and cardiac hypertrophy.