As shown in Figure 2G,H, after treatment for 14 d and 28 d, siRNA, BMSCs and siRNA + BMSCs significantly inhibited the release of IL-1β and TNF-α into the serum compared with PBS rats, revealing that IL-1β/TNF-α siRNAs was able to play a high target gene silencing efficiency in vivo and siRNA, BMSCs and siRNA + BMSCs showed a favorable treatment effect on RA. Here, TNF is linked to rheumatoid arthritis.