TNF and rheumatoid arthritis: Therefore, in the present study, chicken type II collagen-induced-arthritis (CIA) was employed as a RA model to comprehensively evaluate the ameliorating effect of BMSCs transplantation combined with IL-1β/TNF-α siRNAs on RA symptoms from the perspectives of growth status, behavior, immunology and pathology, and to clarify the molecular mechanism mediated by NF-κB signaling pathway, so as to provide theoretical basis for gene combined stem cell therapy for RA.