HTRA2 and infection: Structural analysis showed that two IGHV1-69-encoded Omicron RBD-reactive mAbs Omi-2 and Omi-31 that isolated from Omicron BA.1 breakthrough infection shared the same binding mode with those isolated from primary SARS-CoV-2 ancestral strain infection (Figure 4(B), Figure 2(C), Figure S2B).