A dominant expression of ASIC1 compared to ASIC2 was also reported from human central neuronal cell line cultures [214], associated with a dominant ASIC1a current (strongly inhibited by PcTx1) and a native hASIC1a current was also recorded from neuroblastoma differentiated into neuronal-like phenotype, associated with the co-expression of ASIC2 but not ASIC3, leading to some Mamb-sensitive heterotrimeric ASIC1a/2a [215]. This evidence concerns the gene ASIC2 and neuroblastoma.