ASIC3 and rheumatic disorder: LPC and arachidonic acid (AA) were shown to induce a slow constitutive activation of ASIC3 including the human isoform [21], and high levels of lysophosphatidylcholine (LPC) were measured in synovial fluids of two independent cohorts of patients with rheumatic diseases, correlated with pain outcomes in the cohort of osteaoarthritis (OA) patients [20].