By combining ASIC3-knockout mice and APETx2, ASIC3 was also involved in mechanical hyperalgesia in a mouse model of fibromyalgia induced by repeated intramuscular acid injections [143,157], as well as in a rat reserpine-induced pain model [237], associated with an increased expression of ASIC3 in DRG [237,238], spinal cord and thalamus [238]. The gene discussed is ASIC3; the disease is fibromyalgia.