The overlap of several aberrant CSF proteins in children and young MMC adults, including hyperphosphorylated tau, beta amyloid, alpha synuclein and TDP 43 [1,2,4], drove our current investigation of MMC children and adults with TDP-43 in CSF and brain tissues versus low pollution controls, and we selected hospital-diagnosed amyotrophic lateral sclerosis (ALS) as an example of patients with a clinical syndrome with complex biological determinants characterized by TDP-43 pathology and high TDP-43 lumbar CSF concentrations. Here, TARDBP is linked to amyotrophic lateral sclerosis.