Carlos et al. [113] made a calculation of the frequency and distribution of TDP-43 pathology in 1072 cases, average age 87 years, with AD and TDP-43 pathology and antemortem cognitive studies, including 58% with dementia, 15% with mild cognitive impairment and 27% who were cognitively intact. The gene discussed is TARDBP; the disease is Alzheimer disease.