TARDBP and frontotemporal dementia: The global connectome architecture of FTD subjects is a relevant issue in early TDP-43 pathology, as it allowed researchers such as Shafiei et al. [70] to identify regional early atrophy; i.e., insula—which was identified as the predominant group epicenter of brain atrophy using data-driven and simulation-based methods—with secondary regions in frontal ventromedial and antero-medial temporal areas [70].