In the same reasoning, rats treated with carvedilol with induced periodontitis had reduced levels of pro-inflammatory cytokines (IL-1 β TNF-α), as well as MMP-2, MMP-9, RANK, RANKL, COX-2, and OPG, demonstrating that the medication can influence bone formation / destruction and anti-inflammatory activity in periodontitis .30 This evidence concerns the gene MMP9 and periodontitis.