The anxiety-like emotions were assessed by open field test (OFT), elevated plus maze (EPM), and light-dark box, which revealed significantly longer total distance and increased mean velocity of Gabrb2 KO mice compared to the WT mice (p < 0.05) and HT mice (p < 0.01) and prolonged movement time as compared to the WT mice (p < 0.05) and HT mice (p < 0.05) in the OFT. Here, GABRB2 is linked to Anxiety.