Since mtDNA mutations are reported as a balance needle in determining the metabolic signature of cancers [26,27], but not in these tumor types, we sequenced the whole mtDNA and detected the presence of the m.8828A > G missense mutation of a conserved residue (p.N101S) in the MT-ATP6 gene encoding the corresponding mitochondrial complex V (CV, i.e., ATP synthase) subunit (Figure 3F); such a finding has never been reported regarding somatic cancer tissues before. The gene discussed is MCAT; the disease is cancer.