Alanine aminotransferase (ALT) levels are a primary measure to quantitate liver cell injury in a wide spectrum of liver pathologies, including alcohol-associated liver disease [1,2,3,4], non-alcoholic fatty liver disease/diet-induced steatohepatitis [5,6], as well as cholestatic liver disease and other chronic liver diseases [7,8]. This evidence concerns the gene GPT and metabolic dysfunction-associated steatotic liver disease.