In stress states, as would be the case in cancer, a new glucocorticoid receptor appears, as has been shown in rats under a number of stressful conditions including bearing an AH 130 tumour [176] that is specific for induction of TDO, but not of the other glucocorticoid-inducible enzyme Tyr aminotransferase [177]. This evidence concerns the gene NR3C1 and cancer.