CD40LG and infection: Individuals with Ogawa infections on average had 7.2 (95% CI, 2.0 to 23.7) times higher increases in anti-Ogawa OSP IgM, 3.6 (95% CI, 1.0 to 12.8) times higher increases in anti-Ogawa OSP IgG, and 2.8 (95% CI, 0.7 to 10.3) times higher increases in anti-Ogawa OSP IgA than those with Inaba infections (see Extended Supplement).