F10 and thrombotic disease: The treatment of thrombotic disorders generally requires anticoagulant therapy, which typically starts with parenteral unfractionated heparin (UFH), or low molecular weight heparin (LMWH), followed by subsequent oral warfarin, a vitamin K antagonist, or one of the direct oral anticoagulants, including factor Xa (FXa) inhibitors (rivaroxaban, apixaban, edoxaban) and a direct thrombin (factor IIa, FIIa) inhibitor (dabigatran) [3].