Significant alterations in voltage-dependent anion channel-1 (VDAC1, a mitochondrial protein in the outer mitochondrial membrane that causes a central pore and is considered a major protein for mitochondria-mediated apoptosis) were caused by hierridin B on colon adenocarcinoma cell line HT-29. The gene discussed is VDAC1; the disease is colon adenocarcinoma.