Lipopeptide kalkitoxin, isolated from the Lyngbya majuscula marine cyanobacterium (often reported as Moorea producens), prevented hypoxic HIF-1 induction, reduced the quantity of hypoxia-induced secreted VEGF protein, and prevented tumor angiogenesis, as well as regulated mitochondrial respiration in tumor cells by blocking electron transport chain complex I [108]. Here, HIF1A is linked to neoplasm.