TYR and obesity due to melanocortin 4 receptor deficiency: Phlorofucofuroeckol-A is reported to be present in various brown algae and is a phlorotannin with various biological activities [48], including tyrosinase inhibition and antioxidant, anti-obesity, anti-diabetic, anti-inflammatory, anti-atherosclerotic, anti-hepatotoxic activities [16,17,21,22,24,31,34,35,40,44,49].