Regarding hypercholesterolemia, in the present study, we also have observed that both EEB and the EEB-loaded BSA NPs inhibit the HMGR enzyme and reduce cholesterol intestinal permeation, and the results were comparable to commercial and clinically used drugs such as statins (pravastatin) and ezetimibe (Ezet). This evidence concerns the gene HMGA1 and Hypercholesterolemia.