Hub genes of severe VMC and DCM include VSNL1, GABRA4, GABRB1, ACTG2, SCN1A, NFASC, AQP4, MYH6, COL1A1, and CSRP2, which mainly cluster in extracellular matrix remodeling and sarcomere dysfunction. This evidence concerns the gene SCN1A and familial dilated cardiomyopathy.