AQP4 and familial dilated cardiomyopathy: Hub genes of severe VMC and DCM include VSNL1, GABRA4, GABRB1, ACTG2, SCN1A, NFASC, AQP4, MYH6, COL1A1, and CSRP2, which mainly cluster in extracellular matrix remodeling and sarcomere dysfunction.