Hub genes of severe VMC and DCM include VSNL1, GABRA4, GABRB1, ACTG2, SCN1A, NFASC, AQP4, MYH6, COL1A1, and CSRP2, which mainly cluster in extracellular matrix remodeling and sarcomere dysfunction. The gene discussed is VSNL1; the disease is familial dilated cardiomyopathy.