In the univariate analysis, HRP was significantly associated with the TG/HDL-C ratio as well as with age, male sex, hypertension, dyslipidemia, diabetes mellitus, current smoking, and the use of statins, angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers, calcium-channel blockers, and antidiabetic agents. The gene discussed is ACE; the disease is diabetes mellitus.