In addition, in the univariate analysis, significant stenosis was significantly associated with the TG/HDL-C ratio as well as with age, male sex, hypertension, dyslipidemia, diabetes mellitus, and the use of statins, angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers, calcium-channel blockers, and antidiabetic agents (Table 4). The gene discussed is ACE; the disease is diabetes mellitus.