In addition, the prescription rates of the angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, beta-blocker, and mineralocorticoid receptor antagonist were low, as well as ARNI and SGLT2, because this study included many elderly patients, reflecting Japan’s aging society, and these elderly patients often had hypotension and renal failure [18]. This evidence concerns the gene NR3C2 and Renal insufficiency.