NFKB1 and colitis: The dysregulation of RhoA/ROCK activity in the intestinal epithelium is associated with cytoskeletal dysfunction [47], and the inhibition of RhoA/ROCK protects against DSS- or TNBS-induced colitis in mice by attenuating intestinal epithelial barrier dysfunction [23,48] mediated by the NF-κB-STAT3 signaling pathway [49].