As seen in Figure 4E,F, the protein expressive levels of precursor Srebp-2 (P- Srebp-2) and mature Srebp-2 (N- Srebp-2) were significantly reduced (p < 0.05) in the liver tissues of the STZ-induced T2D ApoE-/- mice compared to that of the control mice. This evidence concerns the gene APOE and type 2 diabetes mellitus.