Therefore, the objective of this study is to investigate the changing pattern of miR-21, miR-122, miR-33a and miR-3064-5p in the circulation and liver of ApoE-/- mice with streptozocin (STZ)-induced T2D and to identify their potential as biomarkers for screening cardiovascular risks in T2D. Here, APOE is linked to type 2 diabetes mellitus.