The augmented expression of miR-146a may represent a disadvantage in males since it can act as a negative regulator of immune activation and can negatively interfere, among others, with the signal transduction and activator of transcription (STAT)-1/interferon (IFN)-γ axis, which in turn can reduce cell-migration, cell cycle activity, and basal oxygen consumption rate in melanoma cells [56,57]. This evidence concerns the gene IFNG and melanoma.