The active-site residues of the Tau protein (PDB ID: 6PXR) (Arg57, Ser52, Ser54, Ser53, Trp100, Asp101, and Glu39) participate in complex formation with its ligands, and this information may help in developing a tau-targeted therapeutics for AD (https://www.rcsb.org/structure/6PXR, accessed on 5 September 2022) [153]. Here, MAPT is linked to Alzheimer disease.