ADAM17 and diabetes mellitus: We found that ADAM17 protein concentration in the tumor samples was higher in patients with diabetes mellitus type 2 (DMT2) (0.28 vs. 0.2 ng/μg protein; p = 0.01) and in the surgical margin was higher both in patients with coexisting DMT2 (0.22 vs. 0.16 ng/μg protein; p < 0.05) and CVD (0.21 vs. 0.13 ng/μg protein; p < 0.01).