The relationship of ADAM proteins with inflammation and carcinogenesis is evidenced, for example, by the results of studies in which obesity has been shown to increase the serum levels of ADAM17 and 28, as well as some pro-inflammatory cytokines such as TNFα (which together lead to the induction of inflammation and tumorigenesis) [9,10]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.