Autophagy is a conserved biological process through which cellular components and damaged organelles are sequestered in autophagosomes for lysosomal degradation, and it is accepted that it is a key mechanism in promoting cancer cell survival and chemoresistance.[16, 17, 18, 19, 20] A key autophagy‐related factor, ATG4B cleaves MAP1LC3/LC3 to generate LC3‐I and is subsequently conjugated to phosphatidylethanolamine (PE), forming lipidated LC3‐II on phagophore membranes.[21, 22] In addition, ATG4B expression has been demonstrated to be positively correlated with cancer chemoresistance. This evidence concerns the gene ATG4B and cancer.