Moreover, the IHC results in the previously established xenograft mouse model showed that the expression level of p62 was significantly increased but those of LC3B and Ki67 (a marker of cell proliferation[31]) were decreased in CRC cells treated with exo‐si‐circATG4B compared with the exo‐si‐NC group (Figure 3I), which further confirmed that exosomal circATG4B induced oxaliplatin resistance by regulating autophagy. The gene discussed is MKI67; the disease is colorectal carcinoma.