showed that upregulation of ATG4B can induce autophagy followed by suppression of cisplatin (DDP) chemosensitivity in gastric cancer cells.[23] In CRC, previous studies have also revealed the effects of ATG4B on enhancing cancer cell chemoresistance to oxaliplatin and 5‐fluorouracil (5‐FU).[24, 25] However, whether the circRNA derived from ATG4B is associated with the process of autophagy to induce chemoresistance in CRC is unclear. The gene discussed is ATG4B; the disease is cancer.