For example, in hepatocellular carcinoma, cancer cell‐derived exosomal circUHRF1 induces natural killer cell exhaustion and causes resistance to anti‐PD1 therapy.[38] Another study reported that exosome‐delivered circRNA (ciRS‐122) promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in CRC.[15] Similarly, in this study, we found that the exosomal circATG4B level was associated with oxaliplatin resistance in CRC. The gene discussed is PKM; the disease is cancer.