For example, circCUL2 regulates cisplatin resistance in gastric cancer by modulating autophagy through the miR‐142‐3p/ROCK2 axis.[40] ATG4B, a human homologue of ATG4 enzymes, can cleave the precursor LC3 to generate LC3‐I, which is subsequently converted into LC3‐II, leading to the promotion of autophagosome formation.[21, 22] Given that ATG4B can enhance autophagy, we speculated that ATG4B‐derived circRNA also performs a function in autophagy. The gene discussed is ROCK2; the disease is gastric cancer.