Accumulating evidence has established that the PI3K/AKT/mTOR pathway is one of the key intracellular signaling pathways, and its activation has recently been found to be frequently aberrantly activated in many tumors and plays a critical role in regulating key physiological and pathological cellular processes, including cell proliferation, invasion, cancer progression, and chemoresistance as well as angiogenesis [31]. The gene discussed is AKT1; the disease is cancer.