As the main regulator of Angptl4 [40, 41], HIF-1 plays a role in promoting arteriosclerosis and dyslipidemia by upregulating Angptl4, inhibiting the expression of LPL, and increasing triglycerides and lipids in CIH-induced lipid metabolism and arteriosclerosis [14]. The gene discussed is HIF1A; the disease is arteriosclerosis disorder.