As the main regulator of Angptl4 [40, 41], HIF-1 plays a role in promoting arteriosclerosis and dyslipidemia by upregulating Angptl4, inhibiting the expression of LPL, and increasing triglycerides and lipids in CIH-induced lipid metabolism and arteriosclerosis [14]. Here, HIF1A is linked to arteriosclerosis.