Moreover, these genes are associated with the IL-17 signaling pathway (MMP9, CCL2, IL-1B, IL-6, CXCL8, and TNF), TNF signaling pathway (ICAM1, IL-1B, MMP9, IL-6, CCL2, and TNF), Cytokine-cytokine receptor interaction pathway (IL-1B, CCL2, IL-6, CXCL8, TNF, and IL-10) and the Yersinia infection pathway (IL-1B, CCL2, FN1, IL-6, CXCL8, IL-10, and TNF), as well as the NF-kappaB signaling pathway (IL-1B, ICAM1, CXCL8, and TNF). The gene discussed is ICAM1; the disease is Yersinia infectious disease.