EPAS1 and neoplasm: In this investigation, we discovered that PFGS combined with Sor could significantly decrease activation of the NF-κB/HIF-2α/SerpinB3 pathway in H22 tumor-bearing mice and SR cells compared with a single treatment, which led to increased antitumor activity, reduced invasion ability of hepatoma cells, and perhaps prevented EMT in hepatoma cells, although further study is needed to validate this.