BRAF mutation status is an important biomarker for personalized management of metastatic melanoma.98–100 In one study, tumor location, shape, first-order, and second-order features from CE-T1W MRIs, alongside a support vector machine classifier were used to predict BRAF mutation status in melanoma-derived BM.101 Akin to previous studies predicting BM mutation status, this model showed an accuracy of 78%, although the study contained a limited number of samples. The gene discussed is BRAF; the disease is metastatic melanoma.