MKI67 and breast cancer: Future research could similarly focus on breast cancer BM subtyping, which can be an important factor for patient outcomes upon diagnosis of metastatic spread.138 Additionally, factors such as KI67 expression, HIF-1α status, and the presence of microvasculature are prognostic factors for BM.139,140 In the context of glioblastoma, it has been shown that radiomics can predict KI67 status suggesting that this is a possibility for BM as well.141,142