PDYN and Alzheimer disease: Here, we study the cross-interaction between Aβ40 and dynorphins based on the premises that: i) DynA is dysregulated in AD [21], ii) dynorphins and Aβ40 share the same location at the brain parenchyma, and iii) potential Aβ40-dynorphins interactions could be driven by electrostatics and hydrophobicity.