AKT1 and pachyonychia congenita: Our study found that PC-derived exosomes inhibited PTEN and activated Akt, while miR-3960-overexpression and TFAP2A-knockdown antagonized this effect, suggesting that the inhibitory effect of miR-3960-overexpressed on PC cell metastasis by inhibiting TFAP2A may be closely related to the regulation PTEN/Akt signaling pathway.